IL4Rα+Myeloid-Derived Suppressor Cell Expansion in Cancer Patients

IL4R Myeloid-Derived Suppressor Cell Expansion in Cancer Patients

Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer

Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...

regulatory t cells and myeloid-derived suppressor cells in patients with peptic ulcer and gastric cancer

background: regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. objective: to investigate and compare tregs and mdscs in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (nud, n=22), peptic ulcer disease...

Myeloid Derived Suppressor Cells: Subsets, Expansion, and Role in Cancer Progression

Cancer immunotherapies have shown considerable promise in pre-clinical studies, but the potency of these interventions has often proved disappointing in vivo. This is in part due to tumor infiltration by myeloid cells, which are usually associated with less favorable clinical outcomes. In the past decade, several distinct subsets of tumor-infiltrating myeloid cells have been described (Movahedi...

γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.

Development of cancer has been linked to chronic inflammation, particularly via interleukin-23 (IL-23) and IL-17 signaling pathways. However, the cellular source of IL-17 and underlying mechanisms by which IL-17-producing cells promote human colorectal cancer (CRC) remain poorly defined. Here, we demonstrate that innate γδT (γδT17) cells are the major cellular source of IL-17 in human CRC. Micr...